Fig. 7

PLGA NPs-mediated silencing of Notch1 enhances 5-FU toxicity in vivo. A In vivo imaging of xenograft-bearing mice after intra-tumoral injection of PBS, PLAG NPs, FAM-labeled si-Notch1, PLAG NPs containing FAM-labeled si-Notch1. B Biodistribution of FAM-labeled si-Notch1 and PLAG NPs containing FAM-labeled si-Notch1 in xenograft mice. C Images of the collected xenograft tumors. D Eventual tumor weight of xenograft mice. E Eventual tumor volume of xenograft mice. F Western blot was used to detect protein expression of NLRP3, Caspase-1, GSDMD-N, IL-18 and IL-1β in tumor tissues of mice. ^*P < 0.05. ^**P < 0.01. ^***P < 0.001