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Fig. 5 | Cancer Nanotechnology

Fig. 5

From: Investigating the specific uptake of EGF-conjugated nanoparticles in lung cancer cells using fluorescence imaging

Fig. 5

EGF-HPPS as nanoprobe for targeting lung cancer cells expressing high level of EGFR in vitro. Confocal imaging of distinguished uptake of EGF-HPPS between: a EGFR positive A549 cells and b EGFR negative H520 cells. c Quantification of cellular uptake of HPPS, HPPS with excess of HDL, EGF-HPPS, EGF-HPPS with excess of HDL or EGF-HPPS with excess of HDL and EGF by H520, A549, and EGFR-GFP-A549 cells within 3 h incubation. d Quantification of cellular uptake of EGF-HPPS by H520, A549, and EGFR-GFP-A549 cells during 3, 6, and 24 h incubation by flow cytometry. e Quantification of cellular uptake of EGF-HPPS by H520, A549, and EGFR-GFP-A549 cells with excess of HDL

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