Fig. 13

a In vivo targeting and imaging subcutaneous tumor model with QD–AFP–Ab probes the spectra analysis of the tumor site (red arrow) and the normal tissue adjacent to the tumor site (green arrow). The fluorescence spectra of tumor site were the same with those of QD–AFP–Ab probes, but there was no characteristic 590-nm peak of the QD at the normal tissue site. b The HE staining of the tumor section. c The confocal microscopic imaging of the tumor section showed the specific binding of QD–AFP–Ab probes to tumor cells. e, f, g The QD distribution in the liver, spleen, and kidneys. The tissue sections were observed with CLSFM. As shown in the figures, QD590 was mainly distributed in the liver, spleen, and kidneys (Chen et al. 2008)