Table 1 Shows the experimental design, dosage, and treatment
Groups | Experimental design | Tumor induction (DMBA treatment 250 mg/ml/kg rat) | Tumor inhibition (treatment: three times in the first 5 days through tail vein injection, 1 day spaced between two administrations) |
|---|---|---|---|
Group I | Normal control | – | – |
Group II | Cancer control | Once/3 months | – |
Group III | Cancer + celecoxib | Once/3 months | Celecoxib (100 μg/kg diluted in PBS) |
Group IV | Cancer + empty liposome | Once/3 months | Empty liposome (equivalent volume of liposomal celecoxib) in PBS |
Group V | Cancer + liposomal celecoxib | Once/3 months | Equivalent to celecoxib concentration 100 μg/kg in PBS |