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Table 8 Effect of cryoprotectants and their concentration on PS of lyophilized NPs after re-dispersion in distilled water

From: Encapsulation of exemestane in polycaprolactone nanoparticles: optimization, characterization, and release kinetics

Cryoprotectant

Ratio

Final average PS in nm (Sf)

Sf/Si

Trehalose

1:1

254.0

1.41a

1:2

250.6

1.39a

1:3

288.4

1.60a

1:4

315.9

1.75

Sucrose

1:1

232.4

1.29a

1:2

220.7

1.22a

1:3

273.5

1.52a

1:4

298.1

1.65

Mannitol

1:1

275.9

1.53

1:2

290.2

1.61

1:3

318.0

1.76

1:4

348.5

1.93

  1. aGood re-dispersibility