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Table 1 MeST of the 9LGS bearing rats without irradiation, after MRT irradiation (i) only, (ii) in presence of DOTAREM® and (iii) in presence of particles (with the same quantity of gadolinium)

From: Advantages of gadolinium based ultrasmall nanoparticles vs molecular gadolinium chelates for radiotherapy guided by MRI for glioma treatment

  Median survival time (Days) Number of rats
Without irradiation 19 9
Only MRT 44 15
MRT irradiation 20 minutes after injection of 56 μL of DOTAREM® ([Gd]3+ = 1 M) 32 8
MRT irradiation 20 minutes after injection of 1.4 mL of DOTAREM® ( [Gd]3+ = 40 mM]) 43 8
MRT irradiation 20 minutes after injection of 1.4 mL of AGuIX nanoparticles ( [Gd]3+ = 40 mM]) 102.5 8