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Fig. 5 | Cancer Nanotechnology

Fig. 5

From: Nanotechnology and cancer: improving real-time monitoring and staging of bladder cancer with multimodal mesoporous silica nanoparticles

Fig. 5

Evaluation of increased contrast and histopatholgical benefits of our nanoparticle technology. MSN bind preferentially to bladder cancer cells relative to normal bladder epithelia in vivo as shown in a series of renderings of T2-weighted MRI scans acquired before (ac) and after (df) intravesicular instillation of Gd2O3–TRITC–MSN. a and d 2-dimensional grayscale view, the tumor (T) is shown before and after injection of particles; note clear labeling of the tumor surface * asterisk. (b, e) 3-dimensional rendering provides further evidence of the particle distribution on the tumor surface. c, f Here the tumor is segmented and rendered with a pseudocolor map. Finger-like projections are revealed which are not observed before the injection of particles (c). Histology confirms anatomical observations and particle penetrations in the structures within the tumor: bright field (g) and fluorescent microscopy (h). Scale bars 1 mm (af); 250 μm (g, h)

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