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Table 2 In vitro toxicology studies of cancer models to AuNP exposure for AuNPs larger than 4 nm

From: Gold nanoparticles for cancer radiotherapy: a review

Size (nm) Coating Cancer cell line Exposure Time (h) Toxicity Ref.
4, 12, 18 CTAB, citrate, cysteine, glucose, biotin K562 leukaemia Human 1–250 nM 72 >25 μM Connor et al. (2005)
4.8 PEG HeLa   1–250 μM 48 IC50 = 0.205 mM Zhang et al. (2012)
12.1 IC50 = 0.477 mM
27.3 IC50 = 0.448 mM
46.4 IC50 = 0.613 mM
33 CTAB, citrate A549   0–120 nM 48 IC50 \(\approx\) 100 nM Patra et al. (2007)
BHK21 No toxicity observed for BHK21 up to these concentrations
35.6 ± 6.7 Cetuximab antibody Panc-1   100 nM   IC50 \(\approx\) 100 nM Glazer et al. (2010)
Cama-1 NA
  1. CTAB cetyltrimethylammonium bromide, PEG polyethylene glycol