Gold nanoparticles for cancer radiotherapy: a review

Cancer Nanotechnology

Table 2 In vitro toxicology studies of cancer models to AuNP exposure for AuNPs larger than 4 nm

Size (nm)	Coating	Cancer cell line		Exposure	Time (h)	Toxicity	Ref.
4, 12, 18	CTAB, citrate, cysteine, glucose, biotin	K562 leukaemia	Human	1–250 nM	72	>25 μM	Connor et al. (2005)
4.8	PEG	HeLa		1–250 μM	48	IC₅₀ = 0.205 mM	Zhang et al. (2012)
12.1						IC₅₀ = 0.477 mM
27.3						IC₅₀ = 0.448 mM
46.4						IC₅₀ = 0.613 mM
33	CTAB, citrate	A549		0–120 nM	48	IC₅₀ \(\approx\) 100 nM	Patra et al. (2007)
33	CTAB, citrate	BHK21		0–120 nM	48	No toxicity observed for BHK21 up to these concentrations	Patra et al. (2007)
35.6 ± 6.7	Cetuximab antibody	Panc-1		100 nM		IC₅₀ \(\approx\) 100 nM	Glazer et al. (2010)
35.6 ± 6.7	Cetuximab antibody	Cama-1		100 nM		NA	Glazer et al. (2010)

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