Fig. 3
From: Cancer characterization and diagnosis with SERS-encoded particles
Adapted with permission from Nima et al. (2014). Copyright 2014, Nature Publishing Group
a Outline of the fabrication steps of silver-coated gold nanorods (Au@Ag nanorods) and corresponding SERS spectra of four different SEPs. The following colors were assigned to a non-overlapping peak from each SERS spectrum: (i) blue (SERS label: 4MBA; Ab: anti-EpCAM); (ii) red (PNTP/anti-IGF-1 Receptor β); (iii) green (PATP/anti-CD44); (iv) magenta (4MSTP/anti-Cytokeratin18). 4MBA 4-mercaptobenzoic acid, PNTP p-nitrobenzoic acid, PATP p-aminobenzoic acid and 4MSTP 4-(methylsulfanyl) thiophenol. b Transmission and SERS imaging of: (i) MCF-7 cell incubated with SEPs; (ii) MCF-7 cell with no SEPs (control); (iii) normal fibroblast cell incubated with SEPs. The cells proceed from of a sample containing just one MCF-7 cell among 90,000 fibroblast cells.