Fig. 8From: Cancer characterization and diagnosis with SERS-encoded particlesAdapted with permission from Qian et al. (2008). Copyright 2008, Nature Publishing Group a ScFv EGFR-conjugated SEPs (plasmonic core: spherical gold nanoparticle; SERS label: malachite green) administered via intravenous tail injection to a nude mouse bearing human head-and-neck squamous cell carcinoma (Tu686) xenograft tumor (3-mm diameter). The ScFv-antibody recognizes the tumor biomarker EGFR. b In vivo SERS spectra were obtained, 5 h after injection, from the tumor site (red) and the liver site (blue) with 2-s signal integration (785 nm excitation). The spectra were background subtracted and shifted for better visualization.Back to article page