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Table 2 Photoactivity of ZnPc and ZnPc–TiO2 on Leishmania promastigotes and different mammalian cell lines

From: The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy

 

Fluency (J/cm2)

IC50 (μM)

CC50 (μM)

Leishmania parasites

Mammalian cell lines

Chagasi

Panamensis

HDFs

THP-1

HepG2

Vero

ZnPc

0

>15

14.76

9.21

7.74

10.70

0.78

2.5a

12.86

6.63

1.08

0.14

0.28

0.24

2.5b

0.19

0.39

0.15

0.02

0.035

0.09

10a

5.63

5.63

0.05

0.17

0.086

0.038

ZnPc–TiO2

0

> 10

> 10

> 10

> 10

> 10

0.087

2.5a

> 10

> 10

5.51

7.45

> 10

0.079

2.5b

> 10

> 10

3.54

0.28

0.43

0.023

10a

> 10

> 10

nd

2.00

5.50

0.001

  1. ZnPc zinc phthalocyanine, IC 50 concentration that induces 50% of parasite inhibition, CC 50 cytotoxic concentration that induces 50% of cell death, HDFs human-derived fibroblasts, THP-1 human macrophages, HepG2 human heptocellular carcinoma cells, nd not disclosed
  2. aLaser light irradiation (670 nm)
  3. bBiological photoreactor irradiation (597–752 nm)