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Fig. 6 | Cancer Nanotechnology

Fig. 6

From: C60 fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes

Fig. 6

The effect of C60 fullerenes and their nanocomplexes with anticancer drugs Cis and Dox on intracellular ROS generation in nonsensitized human peripheral blood granulocytes (a) and monocytes (b). Whole blood samples were treated with mentioned preparations for 30 min, then were stained with carboxy-H2DCFDA (see “Methods”). The fluorescence intensities of 10.000 cells were then analyzed by BD-FACS Calibur. All results are expressed as mean ± SD of three independent experiments. *p < 0.05 compared to basal level of ROS generation in control; **p < 0.01 compared to basal level of ROS generation in control; ***p < 0.001 compared to basal level of ROS generation in control; #p < 0.05 compared to corresponding cells without treatment with PMA; §p < 0.05 compared to cells treated with Cis alone, as analyzed by unpaired t test

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