TY - JOUR AU - McCrudden, Cian M. AU - McBride, John W. AU - McCaffrey, Joanne AU - McErlean, Emma M. AU - Dunne, Nicholas J. AU - Kett, Vicky L. AU - Coulter, Jonathan A. AU - Robson, Tracy AU - McCarthy, Helen O. PY - 2018 DA - 2018/06/01 TI - Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer JO - Cancer Nanotechnology SP - 5 VL - 9 IS - 1 AB - Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the presence of damaged or inappropriate DNA, cancer is a condition particularly suitable for genetic intervention. The RALA peptide has been shown to be a potent non-viral delivery platform for nucleic acids. This study examines the use of RALA to deliver a plasmid encoding inducible nitric oxide synthase (iNOS) as an anti-cancer treatment. SN - 1868-6966 UR - https://doi.org/10.1186/s12645-018-0040-x DO - 10.1186/s12645-018-0040-x ID - McCrudden2018 ER -