TY - JOUR AU - Brown, Jeremy M. C. AU - Hanna, Gerard G. AU - Lampe, Nathanael AU - Villagomez-Bernabe, Balder AU - Nicol, James R. AU - Coulter, Jonathan A. AU - Currell, Fred J. PY - 2018 DA - 2018/11/09 TI - Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework JO - Cancer Nanotechnology SP - 9 VL - 9 IS - 1 AB - A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast cancer MV photon radiotherapy. Two different treatment scenarios, conventional and high Z NP enhanced, were explored with a custom Geant4 application that was developed to emulate the administration of a single 2 Gy fraction as part of a 50 Gy radiotherapy treatment plan. It was illustrated that there was less than a 1% difference in the dose deposition throughout the standard and high Z NP-doped adult female phantom. Application of the RBED framework found that the extent of possible biological response with high Z NP doping was great than expected via the dose deposition alone. It is anticipated that this framework will assist the scientific community in future high Z NP-enhanced in-silico, pre-clinical and clinical trials. SN - 1868-6966 UR - https://doi.org/10.1186/s12645-018-0043-7 DO - 10.1186/s12645-018-0043-7 ID - Brown2018 ER -