Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: the Relative Biological Effective Dose (RBED) framework

Table 2 Phantom breast tissue \(\alpha\) and \(\beta\) values for the minimum, mean and maximum radiosensitisation response scenarios for high Z NP-enhanced photon radiotherapy with 1.9 nm Aurovist AuNPs under 6 MV Linac irradiation

Scenario	\(\alpha\)	\(\beta\)	\(\alpha\)	\(\beta\)
Scenario	(0 μg/ml)		(500 μg/ml)
Minimum	0.024	0.086	0.064	0.087
Mean	0.002	0.079	0.104	0.098
Maximum	0.000	0.072	0.144	0.109

Data taken from Jain et al. (2011) MDA-MB-231 breast cancer cell response. Minimum case \(\alpha\) and \(\beta\) determine by minimising AuNP-doped and maximising conventional cell response within experimental uncertainty. Maximum case \(\alpha\) and \(\beta\) determine by maximising AuNP-doped and minimising conventional cell response within experimental uncertainty

ISSN: 1868-6966