Fig. 2

Cell penetrating peptide RALA enhances the delivery of therapeutic cargo. a RALA is complexed with negatively charged cargo, with particles forming through the formation of electrostatic interactions. b simple schematic of a cell. c Upon endocytosis nanoparticles can become trapped within the endosome. d RALA adopts an alpha-helical confirmation in the low pH of the endosome, allowing for interaction, disruption of the endosomal membrane and the release and trafficking of cargo to target tissues/organelles