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Table 3 Concentration of metabolites and activity of enzymes in blood serum of rats treated with the polymeric nanocarrier (PNC) for 20 days

From: Comb-like PEG-containing polymeric composition as low toxic drug nanocarrier

 

Control group

PNC treated group, 20 days

Aspartate transaminase activity, µkat/l

0.648 ± 0.045

0.538 ± 0.042*

Alanine transaminase activity, µkat/l

0.518 ± 0.034

0.425 ± 0.041*

De Ritis coefficient

1.25 ± 0.05

1.27 ± 0.09

γ-Glutamyltransferase activity, µkat/l

0.285 ± 0.034

0.255 ± 0.21

Creatine phosphokinase activity, µkat/l

2.31 ± 0.02

1.94 ± 0.05*

Alkaline phosphatase activity, µkat/l

2.58 ± 0.34

4.01 ± 0.28*

Lactate dehydrogenase activity, µkat/l

5.48 ± 0.12

3.69 ± 0.07*

α-Amylase activity, µkat/l

2.01 ± 0.09

2.36 ± 0.13

Total protein, g/l

76.5 ± 3.5

67.5 ± 3.2

Glucose, mmol/l

5.18 ± 0.89

6.09 ± 0.78

Urea, mmol/l

4.3 ± 0.2

5.1 ± 0.3

Creatinine, μmol/l

82.5 ± 4.1

70.7 ± 2.9*

Calcium cation, mmol/l

2.50 ± 0.34

3.22 ± 0.51

Iron cation, μmol/l

42.4 ± 2.1

42.5 ± 3.2

Sodium cation, mmol/l

127.5 ± 14.5

141.0 ± 9.8

Chloride anion, mmol/l

111.1 ± 4.9

119.8 ± 12.8

  1. * P ≤ 0.05