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Table 3 The cytostatic activity of F–NP–Doc versus free docetaxel expressed as IC50 value

From: In vitro anticancer activity of folate-modified docetaxel-loaded PLGA nanoparticles against drug-sensitive and multidrug-resistant cancer cells

Incubation time, h

IC50, nM

Doc

F–NP–Doc

24

21.2 ± 2.0

9.3 ± 1.3

48

3.5 ± 0.4

2.5 ± 0.3

72

1.8 ± 0.2

1.0 ± 0.1

  1. HeLa cells were incubated with F–NP–Doc and docetaxel for 24, 48 and 72 h. Cell survival was assessed using the SRB assay
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Cancer Nanotechnology

ISSN: 1868-6966

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