Nanomedicine review: clinical developments in liposomal applications

Cancer Nanotechnology

Table 3 Evaluation of liposomal bupivacaine (LB) effect on pain scores and narcotic consumption

References	Years	Surgery	n	Efficacy at POD 1
References	Years	Surgery	n	VAS score	NRS score	POTO (mg)
Yeung et al. (2018)	2018	Robotic sacrocolpopexy with posterior repair	33	28	–	27.2^a
Mazloomdoost et al. (2017)	2017	Retropubic sling placement	54	8.25	2	13.56
Davidovitch et al. (2017)	2017	Operative fixation of ankle fracture	37	65	–	3.4
Johnson et al. (2017)	2017	Total hip arthroplasty	54	–	3.5	26.3
McGraw-Tatum et al. (2017)	2017	Total hip arthroplasty	40	107.5^d	–	60.6
Sabesan et al. (2017)	2017	Shoulder arthroplasty	34	41^b	2.6	78.6
Abildgaard et al. (2017)	2017	Shoulder arthroplasty	37	40.9^a	–	103.11
Namdari et al. (2017)	2017	Shoulder arthroplasty	78	39^e	–	14.4
Amundson et al. (2017)	2017	Total knee arthroplasty	52	–	3.7	45
DeClaire et al. (2017)	2017	Total knee arthroplasty	47	44.4^b	–	97.7
Smith et al. (2017)	2017	Total knee arthroplasty	104	40^c	–	10.9
Alijanipour et al. (2016)	2016	Total knee arthroplasty	59	26	–	71.20
Barron et al. (2016)	2016	Laparoscopic hysterectomy	32	–	2.79	360

n number of patients, POD postoperative day, VAS visual analogue scale pain score in POD 3 (0–100 range, 0 = “no pain” and 100 = “worst pain”), NRS numerical rating scale pain score in POD 3 (0–10 range, 0 = “no pain” and 10 = “worst pain”), POTO postoperative total opiates consumption
^aMedian consumption of opiates for POD 1–3
^bAt POD 2
^cAverage on POD 0 through 3
^dObtained by integrating serial pain assessments over the entire time interval
^eAt POD 1

ISSN: 1868-6966