Fig. 6

Tissue distribution of gold nanoparticles in necrotic tumor after treatments with Dox@HAuNS + laser. Representative photomicrographs of serial sections of necrotic tumor from DOX@HAuNS + laser-treated liver and stained with hematoxylin and eosin (a, c) or silver enhancer stain with neutral red counterstain for lysosomes (b, d). a, b Gold nanoparticles (black) were present in the necrotic wall of tumor vessels (v) in the inflammatory zone surrounding necrotic regions of VX2 tumor (t). Magnification is 50×, with bars = 500 µm. c, d Gold nanoparticles were accumulated in macrophages and multinucleated giant cells (arrows). Magnification is 400× with bars = 50 µm