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Table 5 Correlation between apoptosis genes

From: Algae-meditated route to cuprous oxide (Cu2O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer

  HDF-p53 HDF-p27 HDF-BAX HDF-BCL2 HDF-CASP3 MDA-p53 MDA-p27 MDA-BAX MDA-BCL2 MDA-CASP3 SKBR3-p53 SKBR3-p27 SKBR3-BAX SKBR3-BCL2 SKBR3-CASP3 T47D-p53 T47D-p27 T47D-BAX T47D-BCL2 T47D-CASP3
HDF-p53 Correlation coefficient 1.000 0.714 0.194 0.278 0.561 0.917 0.576 − 0.421 0.993 0.894 − 0.865 − 0.919 − 0.945 − 0.860 0.706 − 0.979 0.054 0.516 − 0.943 − 0.538
Significance (2-tailed) 0.000 0.494 0.876 0.821 0.621 0.261 0.609 0.723 0.075 0.296 0.335 0.258 0.211 0.341 0.501 0.130 0.966 0.655 0.216 0.638
HDF-p27 Correlation coefficient 0.714 1.000 − 0.549 − 0.475 0.980 0.933 0.984 − 0.936 0.791 0.952 − 0.969 − 0.932 − 0.903 − 0.971 0.007 − 0.557 0.738 0.968 − 0.906 − 0.974
Significance (2-tailed) 0.494 0.000 0.630 0.685 0.127 0.234 0.115 0.229 0.419 0.198 0.159 0.237 0.283 0.153 0.995 0.624 0.472 0.161 0.279 0.144
HDF-BAX Correlation coefficient 0.194 − 0.549 1.000 0.996 − 0.703 − 0.212 − 0.690 0.808 0.077 − 0.267 0.325 0.208 0.136 0.334 0.832 − 0.389 − 0.969 − 0.740 0.143 0.723
Significance (2-tailed) 0.876 0.630 0.000 0.055* 0.503 0.864 0.515 0.401 0.951 0.828 0.789 0.867 0.913 0.783 0.374 0.746 0.159 0.470 0.909 0.486
HDF-BCL2 Correlation coefficient 0.278 − 0.475 0.996 1.000 − 0.640 − 0.128 − 0.625 0.755 0.162 − 0.183 0.242 0.123 0.051 0.252 0.876 − 0.467 − 0.944 − 0.680 0.057 0.661
Significance (2-tailed) 0.821 0.685 0.055* 0.000 0.558 0.918 0.570 0.456 0.896 0.883 0.844 0.921 0.968 0.838 0.320 0.691 0.213 0.524 0.963 0.541
HDF-CASP3 Correlation coefficient 0.561 0.980 − 0.703 − 0.640 1.000 0.844 1.000 − 0.987 0.655 0.873 − 0.901 − 0.841 − 0.800 − 0.905 − 0.191 − 0.381 0.857 0.999 − 0.804 − 1.000
Significance (2-tailed) 0.621 0.127 0.503 0.558 0.000 0.360 0.012* 0.102 0.546 0.325 0.286 0.363 0.410 0.280 0.878 0.751 0.345 0.034 0.405 0.017*
MDA-p53 Correlation coefficient 0.917 0.933 − 0.212 − 0.128 0.844 1.000 0.854 − 0.747 0.958 0.998 − 0.993 − 1.000 − 0.997 − 0.992 0.366 − 0.818 0.447 0.814 − 0.997 − 0.829
Significance (2-tailed) 0.261 0.234 0.864 0.918 0.360 0.000 0.348 0.463 0.185 0.036* 0.074 0.003** 0.049* 0.081 0.762 0.391 0.705 0.394 0.045 0.378
MDA-p27 Correlation coefficient 0.576 0.984 − 0.690 − 0.625 1.000 0.854 1.000 − 0.984 0.669 0.882 − 0.909 − 0.851 − 0.811 − 0.913 − 0.172 − 0.398 0.847 0.997 − 0.815 − 0.999
Significance (2-tailed) 0.609 0.115 0.515 0.570 0.012* 0.348 0.000 0.114 0.534 0.313 0.274 0.351 0.398 0.268 0.890 0.739 0.357 0.046 0.393 0.029*
MDA-BAX Correlation coefficient − 0.421 − 0.936 0.808 0.755 − 0.987 − 0.747 − 0.984 1.000 − 0.525 − 0.784 0.820 0.744 0.694 0.825 0.345 0.228 − 0.928 − 0.994 0.698 0.991
Significance (2-tailed) 0.723 0.229 0.401 0.456 0.102 0.463 0.114 0.000 0.648 0.427 0.388 0.466 0.512 0.382 0.776 0.853 0.243 0.069 0.508 0.085
MDA-BCL2 Correlation coefficient 0.993 0.791 0.077 0.162 0.655 0.958 0.669 − 0.525 1.000 0.940 − 0.918 − 0.959 − 0.977 − 0.914 0.617 − 0.948 0.171 0.614 − 0.976 − 0.634
Significance (2-tailed) 0.075 0.419 0.951 0.896 0.546 0.185 0.534 0.648 0.000 0.221 0.260 0.182 0.136 0.266 0.576 0.205 0.890 0.579 0.140 0.563
MDA-CASP3 Correlation coefficient 0.894 0.952 − 0.267 − 0.183 0.873 0.998 0.882 − 0.784 0.940 1.000 − 0.998 − 0.998 − 0.991 − 0.998 0.313 − 0.784 0.496 0.846 − 0.992 − 0.859
Significance (2-tailed) 0.296 0.198 0.828 0.883 0.325 0.036 0.313 0.427 0.221 0.000 0.038 0.039 0.085 0.045 0.798 0.427 0.669 0.358 0.081 0.342
SKBR3-p53 Correlation coefficient − 0.865 − 0.969 0.325 0.242 − 0.901 − 0.993 − 0.909 0.820 − 0.918 − 0.998 1.000 0.993 0.981 1.000 − 0.255 0.745 − 0.548 − 0.876 0.982 0.888
Significance (2-tailed) 0.335 0.159 0.789 0.844 0.286 0.074 0.274 0.388 0.260 0.038* 0.000 0.077 0.124 0.006** 0.836 0.465 0.631 0.320 0.119 0.304
SKBR3-p27 Correlation coefficient − 0.919 − 0.932 0.208 0.123 − 0.841 − 1.000 − 0.851 0.744 − 0.959 − 0.998 0.993 1.000 0.997 0.991 − 0.370 0.820 − 0.442 − 0.812 0.998 0.826
Significance (2-tailed) 0.258 0.237 0.867 0.921 0.363 0.003** 0.351 0.466 0.182 0.039* 0.077 0.000 0.046* 0.084 0.759 0.388 0.708 0.397 0.042* 0.381
SKBR3-BAX Correlation coefficient − 0.945 − 0.903 0.136 0.051 − 0.800 − 0.997 − 0.811 0.694 − 0.977 − 0.991 0.981 0.997 1.000 0.979 − 0.437 0.860 − 0.376 − 0.767 1.000 0.783
Significance (2-tailed) 0.211 0.283 0.913 0.968 0.410 0.049* 0.398 0.512 0.136 0.085 0.124 0.046* 0.000 0.130 0.712 0.341 0.754 0.443 0.004** 0.427
SKBR3-BCL2 Correlation coefficient − 0.860 − 0.971 0.334 0.252 − 0.905 − 0.992 − 0.913 0.825 − 0.914 − 0.998 1.000 0.991 0.979 1.000 − 0.245 0.738 − 0.556 − 0.881 0.981 0.893
Significance (2-tailed) 0.341 0.153 0.783 0.838 0.280 0.081 0.268 0.382 0.266 0.045* 0.006 0.084 0.130 0.000 0.843 0.471 0.624 0.313 0.126 0.297
SKBR3-CASP3 Correlation coefficient 0.706 0.007 0.832 0.876 − 0.191 0.366 − 0.172 0.345 0.617 0.313 − 0.255 − 0.370 − 0.437 − 0.245 1.000 − 0.835 − 0.669 − 0.242 − 0.430 0.217
Significance (2-tailed) 0.501 0.995 0.374 0.320 0.878 0.762 0.890 0.776 0.576 0.798 0.836 0.759 0.712 0.843 0.000 0.371 0.533 0.844 0.717 0.860
T47D-p53 Correlation coefficient − 0.979 − 0.557 − 0.389 − 0.467 − 0.381 − 0.818 − 0.398 0.228 − 0.948 − 0.784 0.745 0.820 0.860 0.738 − 0.835 1.000 0.150 − 0.332 0.856 0.356
Significance (2-tailed) 0.130 0.624 0.746 0.691 0.751 0.391 0.739 0.853 0.205 0.427 0.465 0.388 0.341 0.471 0.371 0.000 0.904 0.785 0.346 0.769
T47D-p27 Correlation coefficient 0.054 0.738 − 0.969 − 0.944 0.857 0.447 0.847 − 0.928 0.171 0.496 − 0.548 − 0.442 − 0.376 − 0.556 − 0.669 0.150 1.000 0.883 − 0.382 − 0.871
Significance (2-tailed) 0.966 0.472 0.159 0.213 0.345 0.705 0.357 0.243 0.890 0.669 0.631 0.708 0.754 0.624 0.533 0.904 0.000 0.311 0.750 0.327
T47D-BAX Correlation coefficient 0.516 0.968 − 0.740 − 0.680 0.999 0.814 0.997 − 0.994 0.614 0.846 − 0.876 − 0.812 − 0.767 − 0.881 − 0.242 − 0.332 0.883 1.000 − 0.771 − 1.000
Significance (2-tailed) 0.655 0.161 0.470 0.524 0.034 0.394 0.046 0.069 0.579 0.358 0.320 0.397 0.443 0.313 0.844 0.785 0.311 0.000 0.439 0.016*
T47D-BCL2 Correlation coefficient − 0.943 − 0.906 0.143 0.057 − 0.804 − 0.997 − 0.815 0.698 − 0.976 − 0.992 0.982 0.998 1.000 0.981 − 0.430 0.856 − 0.382 − 0.771 1.000 0.787
Significance (2-tailed) 0.216 0.279 0.909 0.963 0.405 0.045 0.393 0.508 0.140 0.081 0.119 0.042* 0.004** 0.126 0.717 0.346 0.750 0.439 0.000 0.423
T47D-CASP3 Correlation coefficient − 0.538 − 0.974 0.723 0.661 − 1.000 − 0.829 − 0.999 0.991 − 0.634 − 0.859 0.888 0.826 0.783 0.893 0.217 0.356 − 0.871 − 1.000 0.787 1.000
Significance (2-tailed) 0.638 0.144 0.486 0.541 0.017* 0.378 0.029* 0.085 0.563 0.342 0.304 0.381 0.427 0.297 0.860 0.769 0.327 0.016* 0.423 0.000
  1. *significant at the 0.05 level
  2. **significant at the0.001 level