Drug loaded into CACNP | Response | References |
---|---|---|
Doxorubicin | Doxorubicin-loaded CACNP was effective in killing MCF-7 and MDB 231 compared to free doxorubicin in a time-dependent manner | |
 | Sensitivity of MCF-7 cell to free doxorubicin and doxorubicin-loaded CACNP was time dependent | Hamidu (2019) |
 | Doxorubicin-loaded calcium carbonate nanoparticle caused death of MG 63 cell by induction of apoptosis. Induction of apoptosis was by up-regulation of p53, Bax and caspases 3, 8 and 9 and down-regulation of the Bcl-2 protein | Kamba et al. (2013b) |
 | Doxorubicin-loaded CACNP showed a similar reduction in cell viability as free doxorubicin in a concentration and time-dependent manner | Fu (2017) |
 | Doxorubicin-loaded CACNP significantly reduced osteosarcoma tumour volume and doxorubicin-related cardiotoxicity in osteosarcoma bearing rats | Fu (2018) |
 | Partial response and progressive canine RECIST response | Danmaigoro (2019) |
Doxorubicin, thymoquinone | Doxorubicin–thymoquinone-loaded CACNP was the most efficient in eliminating breast cancer cells at a lower dose of doxorubicin and thymoquinone | Ibiyeye et al. (2019) |
 | Doxorubicin–thymoquinone-loaded CACNP was most effective among the loaded CACNP in inhibiting CSCs’ properties | Ibiyeye and Zuki (2020) |
Gold | Gold-conjugated calcium carbonate nanoparticle progressively decreased the percentage cell viability of MCF-7 cells | Kiranda et al. 2018) |
Docetaxel | Free docetaxel and docetaxel-loaded CACNP revealed a progressive reduction in percentage viability of MCF-7 cancer cells in a dose and time-dependent manner | Hammadi (2017a) |
 | Docetaxel-loaded CACNP and free docetaxel has similar anticancer effects on 4T1 cells | Hammadi (2017b) |
 | Tumour volume, organ weight, tumour inhibition rate, and tumour metastatic score were significantly lowered in breast cancer bearing docetaxel-loaded CACNP 10 mg/kg Balb/C mice. group | Hammadi (2018) |
Cytarabine | Cytarabine-loaded calcium carbonate nanoparticle significantly ameliorated the cancer effect in major organs of leukaemia-bearing SCID mice | Ghaji (2018) |