Fig. 5
From: Nanotechnology approaches to addressing HER2-positive breast cancer
(Reprinted with permission from near-infrared quantum dots for HER2 localization and imaging of cancer cells (Rizvi et al. 2014). Originally published by Dove Medical Press Limited)
Methodology of bioconjugation of mercaptoundecanoic acid-coated QDs and application for localization of HER2 receptors. Anti-HER2-AB conjugates to the QD surface through an amide linkage. The QD-Anti-HER-AB conjugate then targets and localizes to the HER2 receptors overexpressed on SK-BR-3 cells. Ab, antibody; HER2, human epidermal growth factor receptor 2; QD, quantum dot