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Fig. 6 | Cancer Nanotechnology

Fig. 6

From: Nanotechnology approaches to addressing HER2-positive breast cancer

Fig. 6

(Reprinted with permission from Lee et al. (2015). Copyright 2015, American Chemical Society)

Internalization process of HApt–AuNS in HER2-overexpressed cancer cells. HApt–AuNS binds to HER2 on the plasma membrane, and then the HER2–nanoconstruct complex internalizes in the cell by endocytosis. HER2–HApt–AuNS is transported from endosomes to lysosomes, where HER2 is degraded, inducing cell death

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