TY - JOUR AU - Sosnowska, Malwina AU - Kutwin, Marta AU - Strojny, Barbara AU - Koczoń, Piotr AU - Szczepaniak, Jarosław AU - Bałaban, Jaśmina AU - Daniluk, Karolina AU - Jaworski, Sławomir AU - Chwalibog, André AU - Bielawski, Wiesław AU - Sawosz, Ewa PY - 2021 DA - 2021/01/06 TI - Graphene oxide nanofilm and chicken embryo extract decrease the invasiveness of HepG2 liver cancer cells JO - Cancer Nanotechnology SP - 2 VL - 12 IS - 1 AB - The extracellular matrix (ECM) is a mosaic of various structural and functional proteins that cooperate with the cell, regulate adhesion, and consequently manage its further fate. Liver destruction is accompanied by a disruption of the physicochemical properties of the ECM which deregulates the cell–ECM interaction and can lead to uncontrolled proliferation and neoplastic transformation of cells. Therefore, it can be assumed that ECM modification and restoration of its characteristics for healthy tissue may counteract uncontrolled cell proliferation. The purpose of the presented research model was to optimise the physical characteristics of ECM by introducing a graphene oxide plane/nanofilm (nfGO) and enriching the cell environment with potentially missing proteins by adding a functional protein cocktail (chicken embryo liver extract) and determine the impact of these factors on cell–ECM cooperation and its consequences on adhesion, proliferation, and cell phase, which are factors of the invasiveness of cancer cells. SN - 1868-6966 UR - https://doi.org/10.1186/s12645-020-00073-5 DO - 10.1186/s12645-020-00073-5 ID - Sosnowska2021 ER -