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Table 1 The top 57 proteins from the chicken liver extract divided into functional activities according to UniProt database, including the name of the gene and the molecular mass of the protein (kDa)

From: Graphene oxide nanofilm and chicken embryo extract decrease the invasiveness of HepG2 liver cancer cells

No.

Gene name

Protein name

Molecular mass (kDa)

Adhesion

 1

TJP2

Tight junction protein ZO-2

130.7

 2

LARP1

La-related protein 1

118.6

 3

CDH1

Cadherin-1

97.8

 4

CD2AP

CD2-associated protein

71.2

 5

tr|A0A1D5PRE3|A0A1D5PRE3_CHICK

N-myc downstream regulated

39.0

 6

EPCAM

Epithelial cell adhesion molecule

34.4

 7

MTDH

Metadherin

14.2

 8

BSG

Basigin

Few isoforms

ECM organisation

 9

LAMA1

Laminin subunit alpha-1

339.1

 10

COL12A1

Collagen alpha-1(XII) chain

333.5

 11

FN1

Fibronectin

273.2

 12

COL5A1

Collagen alpha-1(V) chain

184.2

 13

LAMC1

Laminin subunit gamma-1

176.5

 14

PEPD

Xaa-Pro dipeptidase

55.1

 15

VTN

Vitronectin

51.7

 16

PRDX4

Peroxiredoxin-4

29.6

Migration and EMT

 17

PTPN23

Tyrosine-protein phosphatase non-receptor type 23

179.0

 18

FAM98A

Protein FAM98A

58.6

 19

TWF1

Twinfilin-1

55.2

 20

MGLL

Monoglyceride lipase

33.3

 21

TPM1

Tropomyosin alpha-1 chain

32.8

 22

PBLD

Phenazine biosynthesis-like domain-containing protein

32.2

 23

ADI1

1,2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase

21.7

Proliferation and cell cycle

 24

GOLGA2

Golgin subfamily A member 2

140.1

 25

MOV10

Putative helicase MOV-10

109.1

 26

ASMTL

Probable bifunctional dTTP/UTP protein

pyrophosphatase/methyltransferase 70.2

 27

RPA1

Replication protein A 70-kDa DNA-binding subunit

68.0

 28

ARID3A

AT-rich interactive domain-containing protein 3A

67.4

 29

RIC8B

Guanine nucleotide exchange factor B

60.5

 30

CERS2

Ceramide synthase 2

55.1

 31

KRT18

Keratin, type I cytoskeletal 18

46.9

 32

MRPS27

28S ribosomal protein S27, mitochondrial

46.7

 33

TARDBP

DNA-binding protein 43

44.6

 34

CA9

Carbonic anhydrase 9

43.8

 35

DRG1

Developmentally regulated GTP-binding protein 1

40.5

 36

SLC35F6

Solute carrier family 35 member F6

40.2

 37

AIMP2

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

34.5

 38

FBXO6

F-box only protein 6

30.7

 39

HPGD

15-Hydroxyprostaglandin dehydrogenase [NAD(+)]

29.0

 40

PSMD9

26S proteasome non-ATPase regulatory subunit 9

22.7

 41

NIT2

Nitrilase NIT2

22.1

 42

DYNLL1

Dynein light chain

10.3

Apoptosis

 43

HTT

Huntingtin

344.0

 44

PARP1

Poly [ADP-ribose] polymerase

113.1

 45

DNMT3A

DNA (cytosine-5)-methyltransferase 3A

99.0

 46

ATAD3A

ATPase family AAA domain-containing protein 3A

67.2

 47

SGPL1

Sphingosine-1-phosphate lyase 1

61.1

 48

CTSC

Dipeptidyl peptidase 1

59.4

 49

FKBP8

Peptidylprolyl isomerase

44.3

 50

AIFM2

Apoptosis-inducing factor 2

40.6

 51

APIP

Methylthioribulose-1-phosphate dehydratase

26.8

 52

PDCD10

Programmed cell death protein 10

24.7

 53

ENDOG

Endonuclease G, mitochondrial

22.2

 54

FAM162A

Protein FAM162A

17.1

 55

HIGD1A

HIG1 domain family member 1A, mitochondrial

10.7

 56

DYNLL1

Dynein light chain

10.3

 57

NQO1

NAD(P)H dehydrogenase [quinone] 1

Few isoforms