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Fig. 2 | Cancer Nanotechnology

Fig. 2

From: Non-invasive transdermal delivery of chemotherapeutic molecules in vivo using superparamagnetic iron oxide nanoparticles

Fig. 2

SPIONs improve the penetration of DOX into mouse skin. a Unlabeled SPIONs alone (mouse on right), DOX alone (mouse in middle) or unlabeled SPIONs plus DOX (mouse on left) were applied topically to the back skin and right ear of mice. After 2 h, unabsorbed particles and DOX solution were removed by wiping. Mouse whole-body fluorescence images were acquired at the indicated time points after application. b Fluorescence micrographs of frozen sections of the treated area of skin, fixed 48 h after application, showing brightfield, nuclear counterstain (DAPI) and DOX channel images. Representative images of an experiment repeated 3 times

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