Fig. 2From: Non-invasive transdermal delivery of chemotherapeutic molecules in vivo using superparamagnetic iron oxide nanoparticlesSPIONs improve the penetration of DOX into mouse skin. a Unlabeled SPIONs alone (mouse on right), DOX alone (mouse in middle) or unlabeled SPIONs plus DOX (mouse on left) were applied topically to the back skin and right ear of mice. After 2Â h, unabsorbed particles and DOX solution were removed by wiping. Mouse whole-body fluorescence images were acquired at the indicated time points after application. b Fluorescence micrographs of frozen sections of the treated area of skin, fixed 48Â h after application, showing brightfield, nuclear counterstain (DAPI) and DOX channel images. Representative images of an experiment repeated 3 timesBack to article page