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Fig. 3 | Cancer Nanotechnology

Fig. 3

From: Development of Fe3O4 core–TiO2 shell nanocomposites and nanoconjugates as a foundation for neuroblastoma radiosensitization

Fig. 3

Tomographic imaging of targeted MIBG–Fe3O4@TiO2–B-loop nanoconjugates by Cryo-XFM indicates partial nuclear localization of the nanoconjugates. a A single XFM projection of a SK-N-AS cell treated with a 60 µM equivalent treatment of MIBG–Fe3O4@TiO2–B-loop nanoconjugates indicates extensive cytoplasmic and nuclear accumulation of nanoconjugates. Scale bar and elemental concentration indicator (black—no signal to red—highest signal) are located under image. Co-localization image: blue: iodine, red: Ti, green: zinc (overlapping color for all three elements is white). bd Screen captures of different single-angle projections of the tomographic reconstruction of the cell seen in a. Different rotation projections confirm the localization of Ti and Fe in the nucleus. e Rotation projection focused on the iodine signal (indication of MIBG) corresponds to the same locations in the cell nucleus seen in b. f SK-N-DZ cell treated with MIBG–Fe3O4@TiO2–B-loop nanoconjugates, also suggesting nuclear localization of I and Ti

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