Ultrasensitive bioassaying of HER-2 protein for diagnosis of breast cancer using reduced graphene oxide/chitosan as nanobiocompatible platform

Table 1 The comparison of the proposed ECL protocol with other strategies for HER-2 determination

Detection technique	Employed technique	Employed materials	LOD	LDR	Refs.
EC	DPV (anodic striping voltammetry)	Fe3O4–Au NPs–AgNPs	20 fg/mL	0.0005 -50 ng/mL 0.0005 -50 ng/mL	Shamsipur et al. (2018)
EC	Anodic stripping voltammetry	Gr NSs^a CdSe QDs	100 fg/mL and 1 pg/mL in PBS and serum	0.0001–0.1 and 0.1–10,000 ng/mL	Shiddiky et al. (2012)
EC	EIS DPV	TiO2 nanofibers	185 fg/mL	1.0 fM-0.1 μM for EIS 0.1 pM − 0.1 μM for DPV	Ali et al. (2016)
EC	EIS	ZnO nanofibers	185 fg/mL	1.0 fM-0.5 µM	Ali et al. (2015)
EC	SWV	Au NPs	0.5 pg/mL	1 pg/mL to 1 ng/mL	Li et al. (2018)
EC	DPV	Fe3O4 NPs Au NPs	0.995 pg/mL	0.01–10 and 10–100 ng/mL	Emami et al. (2014)
EC	Amperometry	Au NPs	12 pg mL	0.001–10 ng/mL	Carvajal et al. (2018)
EC	Impedimetric	Au NPs	0.01 ng/mL	0.01–100 ng/mL	Sharma et al. (2018)
Colorimetric		AuNPs	10 nM	0 M–99 nM	Ranganathan et al. (2020)
Optical	Fluorescent	Ag NCs^b	0.0904 fM	8.5 fM to 225 fM	Zhang et al. (2019)
Piezoelectric			0.0253 ng/mL	0 to 3 ng/mL	Loo et al. (2011)
ECL	ECL	[Ru(bpy)₃]²⁺	1 fM	1 fM to 1 nM	This project

ISSN: 1868-6966