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Fig. 8 | Cancer Nanotechnology

Fig. 8

From: Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood–brain barrier model

Fig. 8

Effect of peptide-modified LPN on the junctional morphology and protein expression of bEnd.3 cells. A Immunostaining of the TJ proteins ZO-1 and claudin-5 after the treatment of bEnd.3 cells with Afa, Afa/LPN-FD7, and Afa/LPN-CCD for 48 h observed through confocal laser scanning microscopy (magnification, 1500x). Green: ZO-1. Red: claudin-5. Blue: the cell nuclei stained with DAPI. B Protein expression levels of claudin-5, ZO-1, and E-cadherin were detected through Western blot after the above treatment in bEnd.3 cells

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Cancer Nanotechnology

ISSN: 1868-6966

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