Table 1 Effect of the surfactant:cholesterol and Span 60:Tween 60 with various molar ratios on entrapment efficiency (EE %), size and PDI in melittin-loaded niosome
Formulations | Surfactant:cholesterol (molar ratio) | Span 60:Tween 60 (molar ratio) | Drug concentration (mg/ml) | Sonication time (min) | Vesicle size (nm, average ± SD) | Polydispersity index (average ± SD) | EE (%) (average ± SD) |
|---|---|---|---|---|---|---|---|
T1 | 1:1 | 100:0 | 1 | 5 | 197.4 ± 8.3 | 0.175 ± 0.024 | 60.25 ± 1.75 |
T2 | 1:1 | 50:50 | 1 | 5 | 121.4 ± 8.7 | 0.211 ± 0.012 | 79.32 ± 1.34 |
T3 | 1:1 | 0:100 | 1 | 5 | 158.4 ± 6.5 | 0.192 ± 0.021 | 67.21 ± 0.92 |
T4 | 2:1 | 100:0 | 1 | 5 | 235.7 ± 10.1 | 0.254 ± 0.016 | 51.33 ± 2.78 |
T5 | 2:1 | 50:50 | 1 | 5 | 165.3 ± 9.2 | 0.184 ± 0.008 | 75.45 ± 2.34 |
T6 | 2:1 | 0:100 | 1 | 5 | 208.9 ± 5.6 | 0.224 ± 0.017 | 64.75 ± 1.52 |