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Table 2 Applications of graphene oxide-based nanomaterials for anticancer drug and gene delivery

From: Recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment

Nanocomposites Delivered drug/gene Fabrication method Highlights of the study Ref.
PEG–GO–SN38 SN38 Non-covalent interactions  30% release in serum; IC50 values:  6 nM Liu et al. (2008)
PEG–GO–PTX PTX Non-covalent interactions Low concentration and short time, for improving the bioavailability of PTX Xu et al. (2014)
FA-FGO–DOX DOX Non-covalent interactions Much higher cancer cell inhibition than pure DOX under the same conditions Liu et al. (2018)
FA-BSA–GO–DOX DOX Non-covalent interactions Drug loading efficiency at 30.43%; higher drug release at pH 5.0 Ma et al. (2017)
GA–GO–DOX DOX Non-covalent interactions High anti-proliferative effect on tumor cells Nascimento et al. (2016)
CS–GO–DOX DOX Non-covalent interactions Higher drug release at pH 5.3; better inhibitory effect on tumor growth Wang et al. (2018)
GO–MS–CPT CPT Adsorption Stimuli-responsive controlled release Tran et al. (2018)
NGO–SS–DOX DOX Covalent grafting Redox-responsive controlled release Chen et al. (2014a, b, c)
GO–ssDNA ssDNA Non-covalent interactions GO platform for the detection of DNA Lu et al. (2009)
GOCLNPs–pDNA pDNA Non-covalent interactions Achieved binding to double-stranded DNA Di Santo et al. (2019)
GO–FACO+–siRNA–DOX siRNA Non-covalent interactions Targeted delivery for drugs and genes Cao et al. (2013)
PEG–PEI–FA-GO–siRNA siRNA Non-covalent interactions Non-viral vector delivered efficiently to tumor tissues Du et al (2018)
PEG–PEI–GO–pDNA–siRNA siRNA/pDNA Non-covalent interactions Use photothermally enhanced intracellular trafficking of nanocarriers for light controllable gene delivery Liu et al. (2013a; b, c)