Illustration of TiO2 nanosticks-loaded temozolomide treatment and activation by ultrasound to ablate the TMZ-resistant glioblastoma multiforme. The ultrasound has a triple action therapeutic effect on GBM by (I) enhancing the nanomedicine permeability, (II) release of TMZ from TiO2 nanosticks, and (III) generation of reactive oxygen species for sensitization of GBM to TMZ