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Table 1 Half-maximal inhibitory concentration (IC50) of the free Ber and C60–Ber nanocomplexes on LLC cells viability

From: Antitumor efficiency of the natural alkaloid berberine complexed with C60 fullerene in Lewis lung carcinoma in vitro and in vivo

IC50, µM

24 h

48 h

72 h

Ber

43 ± 4

25 ± 2

17 ± 2

1:2 C60–Ber

39 ± 4

22 ± 2

14 ± 1*

1:1 C60–Ber

26 ± 3*

13 ± 2*

7.5 ± 2.3*

2:1 C60–Ber

6.4 ± 1.7*

4.0 ± 1.6*

0.8 ± 0.3*

  1. *p ≤ 0.01 compared to free Ber