Fig. 6

In vivo and vitro receptor binding of GNP theranostic nanomedicine on gastric cancer tissues. Fluorescence in different filters (c) shows the presence of GNP nanoparticles and doxorubicin in tissue. Fluorescence only in tissue portion and not on slide showed receptor targeting and binding of theranostic nanomedicine to tissue. Nanocomposites due to doxorubicin presence give golden fluorescence under blue excitation filter. a The cellular tracking of GNP theranostic nanomedicine in vivo at different time points. Figure shows GNP theranostic nanomedicine binds to the receptor with different intensities at different time points. Maximum binding can be seen at 12 h and the most affected portions show the presence of more drugs. The concentration of nanoparticles and drug reduces after 12 h and at 48 h and, at 72 h, traces remain with still some nanomedicine at the most affected portions. b (fluorescent intensity graph) The maximum binding of nanomedicines to receptor at 6 h that gradually reduces. Nanoparticles give blue and green, and doxorubicin gives red fluorescence. Intensity calculation is shown