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Table 4 Effect of nanoLPG on clinical and behavioral parameters

From: Promising self-emulsifying drug delivery system loaded with lycopene from red guava (Psidium guajava L.): in vivo toxicity, biodistribution and cytotoxicity on DU-145 prostate cancer cells

Parameter

Control

NanoLPG

Day 0

Day 28

Day 0

Day 28

Stimulant

Hyperactivity

0

0

0

0

Agressiveness

0

0

0

0

Tremors

0

0

0

0

Convulsion

0

0

0

0

Piloerection

0

0

0

0

Depressive

Ptosis

0

0

0

0

Nose bulge

0

0

0

0

Cheek bulge

0

0

0

0

Ear position

0

0

0

0

Whisker change

0

0

0

0

Sedation/Anesthesia/Analgesia

0

0

0

0

Ataxia

0

0

0

0

Righting reflex

0

0

0

0

Catatonia

0

0

0

0

Loss of corneal reflex

0

0

0

0

Loss of auricular reflex

0

0

0

0

Autonomic nervous system-related

Diarrhea

0

0

0

0

Constipation

0

0

0

0

Lacrimation

0

0

0

0

Salivation/Vomit

0

0

0

0

Cyanosis

0

0

0

0

Others

Ambutation

0

0

0

0

Self-cleaning (grooming)

0

0

0

0

Climb

0

0

0

0

Vocalization

0

0

0

0

Abdominal writhes

0

0

0

0

Deaths

0

0

0

0

  1. 0 = without effect. N = 9 animals per group