Synergistic effect of folate-conjugated polymers and 5-fluorouracil in the treatment of colon cancer

Cancer Nanotechnology

Table 1 Summary of molecular weights of copolymers based on SEC

Polymer	wt% FA_th^a	wt% FA^b	M_n,th^c (g mol⁻¹)	M_n,SEC^d (g mol⁻¹)	Ð^d
PHEA	0	–	10,210	8300	1.97
PX-0	0	–	19,810	16,700	1.56
PX-1	6	1	21,200	18,000	1.73
PX-2	15	4	23,300	22,300	1.83
PX-3	26	13	26,780	24,200	2.10
PX-4	62	–	51,590	–	–

^awt% FA_th = (equiv_FA^. M_FA^. conv_FA): M_{n, th}
^bCalculated using the calibration curve of FA absorbance at 280 nm in distilled H₂O vs. concentration (Additional file 1: Fig. S6)
^cM_{n, th} = M_CTA + M_HEA·equiv_HEA·conv_HEA + M_NVCL·equiv_NVCL·conv_NVCL + equiv_FA·M_FA^. conv_FA; numbers of equivalents and degrees of conversion are taken from the PHEA and PX-0 synthesis procedure and Additional file 1: Table S1; we assume that the conversion of folic acid is quantitative
^dMeasured by SEC-RI-MALS

ISSN: 1868-6966