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Table 2 Kinetic equations of BA release from FA-BSANPs/BA

From: Baicalin-loaded folic acid-modified albumin nanoparticles (FA-BSANPs/BA) induce autophagy in MCF-7 cells via ROS-mediated p38 MAPK and Akt/mTOR pathway

pH of release medium

Fitting curve

Regression equation

R2

7.4#

First-order equation

Mt = 89.14(1−e−0.12t)

0.98184

6.5

Zero-order equation

Mt = 1.55t + 26.01

0.79138

First-order equation

Mt = 84.78(1−e−0.11t)

0.97805

Higuchi equation

Mt = 13.29t0.5 + 4.79

0.93049

5.5

Zero-order equation

Mt = 0.89t + 19.99

0.68458

First-order equation

Mt = 51.59(1−e−0.15t)

0.93788

Higuchi equation

Mt = 7.74t0.5 + 7.43

0.83477

  1. Mt: cumulative release rate of drug (%)
  2. t time (h)
  3. #Data of pH7.4 were quoted from reference (Meng et al. 2021), and we have obtained permission from the copyright holder to reproduce it