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Table 2 Kinetic modeling of docetaxel (DTX) and curcumin (CUR) release from different nanoparticle formulations

From: Synergistic co-administration of docetaxel and curcumin to chemoresistant cancer cells using PEGylated and RIPL peptide-conjugated nanostructured lipid carriers

 

Zero-order

First-order

Higuchi

K0 (μg/h)

r2

K1 (h−1)

r2

KH (h−0.5)

r2

DTX-pNLC

2.0776

0.7027

0.0145

0.7957

15.7216

0.9920

DTX-P/R-NLC

2.1034

0.7254

0.0143

0.7976

15.6762

0.9954

CUR-pNLC

0.8423

0.8873

0.0050

0.9287

6.5096

0.9765

CUR-P/R-NLC

1.7106

0.9057

0.0097

0.9435

9.1374

0.9476

  1. K0, zero-order rate constant; K1, first-order rate constant; KH, Higuchi equation’s rate constant; r2, correlation coefficient
  2. pNLC, plain nanostructured lipid carrier; P/R-NLC, PEGylated and RIPL peptide-conjugated nanostructured lipid carrier
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Cancer Nanotechnology

ISSN: 1868-6966

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