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Fig. 9 | Cancer Nanotechnology

Fig. 9

From: Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and metabolic reprogramming

Fig. 9Fig. 9

Regulatory role of DDMPlusAF and/or 6 Gy on signaling effectors implicated in metabolic reprogramming of BCCs. The protein expression of a AKT, b AMPK, c SIRT-1, d TGF-β, e PGC-1α were detected by western blotting (β-actin, as housekeeping protein), f gene expression of ERR-α via RT-PCR, and g, h representative western blot analysis, SDS-PAGE of MCF-7 and MDA, respectively. All group values are represented as mean ± SEM. a1p < 0.001, a2p < 0.01, a3p < 0.05 vs. control; b1p < 0.001, b2p < 0.01, b3p < 0.05 vs. DDMPlusAF group; c1p < 0.001, c3p < 0.05 vs. 6 Gy group. Blue columns denote MCF-7 cells and red columns stand for MDA-MB-231 cells

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