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Table 9 The changes in the expression of apoptosis-related genes in the TUBO tumor in the mice receiving different treatments

From: Antiproliferation effects of nanophytosome-loaded phenolic compounds from fruit of Juniperus polycarpos against breast cancer in mice model: synthesis, characterization and therapeutic effects

Genes

Gene expression (fold changes)

S.E.M

T1

T2

T3

T4

Up-regulated genes

 Bax

1.0d

2.6c

3.4b

4.8a

0.09

 Caspase-3

1.0d

1.9c

2.7b

3.9a

0.11

Down-regulated genes

 Bcl2

1.0d

2.3c

3.6b

5.2a

008

  1. Control (T1); mice receiving HPF (50 mg TPC/Kg/BW) (T2); mice were receiving nanophytosome-loaded HPF (50 mg TPC/Kg/BW) (T3) and mice receiving tamoxifen (0.4 mg/kg/BW similar dose to the clinical dose in humans) as an antiproliferative drug (T4). Different letters (a, b, c, d) in the same row represent significant difference (p < 0.05). The analysis was performed in triplicates