Fig. 9
From: Nanomicelles co-loaded with doxorubicin and salvianolic acid A for breast cancer chemotherapy
Evaluation of cardiotoxic effects in nude mice bearing MCF-7 cancer cells by A heart weight index, B LDH, CK, and cTnT in serum, C SOD, MDA in heart tissues (**p < 0.01 and *p < 0.05, compared with NC, ##p < 0.01 and #p < 0.05, compared with CPMSD, &&p < 0.01 and &p < 0.05, compared with DOX), and D light microscope observation (×400) of pathological change in mice left ventricles (with the black arrows indicating representative morphological changes, such as cell necrosis, superficial cytoplasm, and nucleus and transverse structure loss)