Frankincense essential oil nanoemulsion specifically induces lung cancer apoptosis and inhibits survival pathways

Cancer Nanotechnology

Table 3 IC₅₀ and fold changes of lung cancer A549 and normal WI-38 cell lines upon different treatments

Incubation period	IC₅₀ and fold changes	Lung cancer cell line					Normal cell line
Incubation period	IC₅₀ and fold changes	F0	F1	F2	PIN	DOX	F0	F1	F2	PIN	DOX
4 h	IC₅₀	64.11	60.34	52.15	72.47	58.03	77.81	85.62	88.10	72.39	84.64
	FC1	1.0	1.06	1.23	0.88	1.10	1.0	0.91	0.88	1.07	0.92
	FC2	0.91	0.96	1.11	0.80	1.0	1.09	0.99	0.96	1.17	1.0
24 h	IC₅₀	60.12	55.42	47.07	66.27	54.11	72.98	81.85	83.65	69.19	79.16
	FC1	1.0	1.08	1.28	0.91	1.11	1.0	0.95	0.93	1.12	0.98
	FC2	0.90	0.98	1.15	0.82	1.0	1.08	0.97	0.95	1.14	1.0
48 h	IC₅₀	47.89	38.72	30.50	54.58	45.38	62.07	72.47	72.74	60.21	68.65
	FC1	1.0	1.24	1.57	0.88	1.06	1.0	0.86	0.85	1.03	0.90
	FC2	0.95	1.17	1.49	0.83	1.0	1.11	0.95	0.94	1.14	1.0
72 h	IC₅₀	34.60	22.22	14.88	41.29	32.09	50.30	65.70	66.34	53.44	61.88
	FC1	1.0	1.56	2.32	0.84	1.08	1.0	0.77	0.76	0.94	0.81
	FC2	0.93	1.44	2.16	0.78	1.0	1.23	0.94	0.93	1.16	1.0

FC1: Fold change (1), the ration between IC₅₀ of F0 to that of all other tested formulas and compounds
FC2: Fold change (2), ration between the IC₅₀ DOX to that of all other tested formulas and compounds

ISSN: 1868-6966