Table 1 AuNPs and different 2D nanomaterial assisted SPR technology in the detection of cancer biomarkers
Cancer biomarker | Signal amplification | Sensing performance | References |
|---|---|---|---|
CTC | AuNPs | DL: 1 cell/mL DR: 101 ~ 105 cell/mL RR: 93.86% ~ 111.21% RSD: 2.78% | Huang et al. (2020a) |
O-GlcNAc | AuNPs | DL: 4.65 × 1013 mol/L DR: 4.65 × 10–12 ~ 4.65 × 10–7 mol/L RSD: 2% | Gao et al. (2018) |
miRNA let-7a | AuNPs | DL: 0.8 fM DR: 0 ~ 2 pM | Nie et al. (2018) |
MCF-7 exosome | Dual AuNPs | DL: 5 × 103 exosomes/mL RSD: 3.3% | Wang et al. (2019) |
PSA | AuNPs–SiO2 layer | DL: 0.1 ng/mL DR: 0.1 ~ 100 ng/mL | Jung et al. (2009) |
miRNA-21 | Ag@AuNPs | DL: 0.6 fM DR: 0 ~ 10 pM RSD:2.5% | Liu et al. (2017b) |
FAP | Graphene | DL:5 fM DR: 5 ~ 500fM | He et al. (2017) |
exosome | Graphene | DL:20 exosomes/mL DR:5 × 103 ~ 5 × 105 exosomes/mL | Zma et al. (2021) |
CK19 | GO | DL: 0.05 pg/mL DR:0.001 ~ 100 pg/mL | Zhong et al. (2015) |
hCG | GO | DL: 1.15 pM DR: 1.15 ~ 28.7 pM | Chiu et al. (2018) |
CEA | rGO-AuNPs | DL: 0.12 ng/mL DR: 0.6 ~ 80 ng/mL RR: 95.9% ~ 10.5% | Feng et al. (2014) |
miRNA141 | GO-AuNPs | DL: 0.1 fM DR: 0.1 pM ~ 2 nM RR: 99.4% ~ 101% | Li et al. (2017) |
miRNA141 | GO-AuNPs | DL: 1 fM DR: 0 pM ~ 50 pM RSD: 1% | Wang et al. (2016b) |
CYFRA21-1 | MoS2 | DL: 1 fM DR: 0 pM ~ 50 pM RSD: 4.2% RR: 90% ~ 103% | Chiu and Yang (2020) |
PSA | MoS2 QC-C3N4–AuNPs | DL: 0.71 pg/mL DR: 1 ~ 250 ng/mL RSD: 1.52% RR: 92.7% ~ 109% | Duan et al. (2018) |
tumor DNA | BP | DL: 50 fM DR: 50 fM ~ 80 pM RSD: RR: | Huang et al. (2020b) |
ssDNA | BP | DL: 0.2 pg/mL DR: 1 pg/mL ~ 10 mg/mL | Peng et al. (2017) |
miRNA-21 miRNA-155 | Antimonene | DL: 10 aM DR: 10 pM ~ 10 aM | Xue et al. (2019) |
CEA | MXene | DL: 0.15 fM DR: 0.001 ~ 1000 pM | Wu et al. (2018) |