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Table 1 Effect of control groups, free DOX/SOR and NPs groups on serum levels of total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase

From: A novel pH- and glutathione-responsive drug delivery system based on in situ growth of MOF199 on mesoporous organic silica nanoparticles targeting the hepatocellular carcinoma niche

Group

TP (g/L)

ALT (U/L)

AST (U/L)

AKP(U/L)

LDH (U/L)

PBS

65.33 ± 5.73

33.33 ± 4.19

39.33 ± 4.11

75.33 ± 7.85

174.67 ± 12.28

MONs@MOF-199

64.33 ± 4.50

35.67 ± 3.68

39.00 ± 4.90

80.00 ± 10.03

189.33 ± 7.13

free DOX/SOR

59.67 ± 6.24

29.33 ± 4.50

30.67 ± 3.86

89.00 ± 9.09

234.67 ± 11.09

D/S@MM

61.33 ± 7.59

27.00 ± 2.16

32.67 ± 5.31

83.33 ± 4.19

197.67 ± 16.36

D/S@SPMM

64.33 ± 6.13

32.33 ± 4.19

37.00 ± 4.55

76.33 ± 4.92

181.67 ± 14.06

  1. TP total protein; ALT alanine aminotransferase; AST aspartate aminotransferase; AKP alkaline phosphatase; and LDH lactate dehydrogenase
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Cancer Nanotechnology

ISSN: 1868-6966

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