Skip to main content
Fig. 5 | Cancer Nanotechnology

Fig. 5

From: Carbon nanoparticles induce DNA repair and PARP inhibitor resistance associated with nanozyme activity in cancer cells

Fig. 5

CNPs induced common pathways analysis. a Venn diagram of the soybean and beet CNPs target proteins of intersections. Reactome analysis showing DNA repair is highly enriched in intersections. b Protein–protein interaction network topology with nodes. c Volcano plots of the proteins quantified during the shotgun sequencing data. The green dots are significantly down-regulated proteins; the red dots are significantly upregulated proteins (fold change is more significant than 1.2 times and p-value  < 0.05), and the blue dots are proteins with no significant changes. d-e Confocal images of PC3 cells DNA repair induced by beet-derived CNPs. Scale bar, 20 µm. Different counter acting colors were used from the original confocal color for indicating the merged effect. For example, CNPs (green) and BRCA1 (red) colors are merged as yellow, indicating less co-localizations

Back to article page