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Fig. 6 | Cancer Nanotechnology

Fig. 6

From: Carbon nanoparticles induce DNA repair and PARP inhibitor resistance associated with nanozyme activity in cancer cells

Fig. 6

Carbon nanoparticles bind DNA, induce DNA mutation, and cause DNA damage repair response through PARP. a CNPs bind double-strand (ds) or single-strand (ss) DNA detected by DNA agarose gel electrophoresis. b Negative charges by Glu or SDS interfere with the binding. c CNPs compete with dyes to bind DNA. 1. soybean CNPs; 2. soybean CNPs and DNA; 3. dye; 4. dye and DNA; 5. soybean CNPs and dye; 6. soybean CNPs, dye, and DNA. d DNA mutations induced by CNPs-DNA interactions in a plasmid sequencing. e Optimised geometries of HB complexes modeling DNA and CNPs interaction modes. Legend of colors: white (H), grey (C), blue (N), red (O), and orange (P). f HR-AFM images of CNPs binding to DNA circular forms of plasmid DNA. Scale bar, 5 µm or 500 nm as indicated

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