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Table 3 CI data for nonconstant combination: CET/ESA-NPs

From: Preparation and characterization of cetuximab-loaded egg serum albumin nanoparticles and their uses as a drug delivery system against Caco-2 colon cancer cells

Dose CET (IC50)

Dose ESA-NPs (IC50)

Effect

CI

1.0

1.0

0.96

0.60102

1.0

2.0

0.80

0.07794

2.0

1.0

0.49

0.01282

1.0

4.0

0.89

0.27103

4.0

1.0

0.68

0.05239

1.0

9.0

0.54

0.08574

9.0

1.0

0.53

0.03871

  1. CI: combination index; effect: mean optical density of treated cells by MTT assay. All combination ratios show a synergistic effect between cetuximab and ESA-NPs, but the ratio 2:1 was the most efficient
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Cancer Nanotechnology

ISSN: 1868-6966

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