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Fig. 4 | Cancer Nanotechnology

Fig. 4

From: Curcumin-loaded nanocomplexes alleviate the progression of fluke-related cholangiocarcinoma in hamsters

Fig. 4

Representative micrographs of xenobiotic-induced cholangiofibrosis and cholangiofibroma in hamster livers with Opisthorchis viverrini infection and receiving NDMA, after 5 months. A–C Early development of cholangiofibrosis, initially associated with oval cell proliferation and bile duct hyperplasia. A A lesion showing portal proliferation of bile ductules, lined by a single layer of cuboidal or columnar epithelium along with mucin-containing cells. B Ductular reaction cells are positive for AFP: a marker for bipotential oval cells. C AB/PAS: acid mucin was present in goblet cells (intestinal metaplasia). D–F Cholangiofibrosis consists of dilated to cystic bile ducts filled with mucus, cellular debris and surrounded by inflammatory cell infiltrates and connective tissue. E AB/PAS. F CK 19 was present in both biliary gland and glands with intestinal metaplasia. G–I Cholangiofibrosis, progressing lesion. G There is aggregation of the adjacent portal lesions, as well as ductal proliferation and cystic dilatation of metaplastic glands, peribiliary fibrosis and a mixed inflammatory cell infiltrate. H–I The lesion is positive for both AFP and CK19, indicating oval cell proliferation and developed in the line of cholangiocytes. J–L Cholangiofibroma. J Cholangiofibroma, expanding nodular formation of glandular and stroma components of cholangiofibrosis. K–L The lesion is positive for both AFP and CK19, similar to cholangiofibrosis

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