Fig. 4

STn-targeted nanoparticles reach sTn-expressing tumors in vivo. Radio thin-layer chromatogram of A ^99mTc-non-targeted or B ^99mTc-sTn-targeted NPs with acetone as mobile phase. The radiochemical purity (RCP) > 98%. C Schematic representation of the radiolabeling process followed by tail vein injection of NPs in mice. D Representative static small animal SPECT/CT images 1-h after injection of 37 MBq of ^99mTc-non-targeted or ^99mTc-sTn-targeted NPs in MKN45-ST6GalNAc-I tumor-bearing Balb/c nude mice. Images are displayed as representative SPECT/CT images of tumor. Standard uptake values (SUV) for tumors are shown. Semiquantitative data are shown as mean ± SEM from 3 individual experiments